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Endocrine Abstracts

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ea0029p814 | Endocrine tumours and neoplasia | ICEECE2012

Efficacy of Everolimus to prevent hypoglycemia in patients with metastatic insulinomas: for the French group of endocrine tumors (GTE-Renaten)

Bernard V. , Lombard-Bohas C. , Goichot B. , Rohmer V. , Guimbaud R. , Niccoli P. , Chougnet C. , Ruszniewski P. , Baudin E.

Background: Refractory hypoglycemia in patients with metastatic insulinomas (RHMI) is an important cause of morbidity and mortality and everolimus could be a new therapeutic option.Methods: We conducted a restrospective multicentric study within the French group of endocrine tumors to evaluate the time to first symptomatic recurrence (TSR) in patients with RHMI after everolimus initiation. Ongoing hyperglycemic medical options and safety were recorded.</...
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ea0029oc9.6 | Endocrine Tumours &amp; Translation | ICEECE2012

First in vitro study of human gastroenteropancreatic-neuroendocrine tumors: comparative effect of octreotide and pasireotide

Mohamed A. , Blanchard M. , Albertelli M. , Niccoli P. , Monges G. , Garcia S. , Moutardier V. , Delpero J. , Enjalbert A. , Florio T. , Ferone D. , Saveanu A. , Barlier A.

Somatostatin analogs (SSAs) such as octreotide (OCT) are currently effective in controlling most hypersecretion associated symptoms of Gastoenteropancreatic-neuroendocrinetumors (GEP-NETs). The results of the phase IIIb PROMID trial showed that OCT doubled time to progression for patients with metastatic neuroendocrine midgut tumors compared with placebo. SSAs act on different intracellular pathways through different somatostatin receptor (Sst) subtypes. While OCT is mainly an...
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ea0029oc7.1 | Adrenal Clinical | ICEECE2012

Progression-free survival without treatment of malignant pheochromocytoma and paraganglioma at one year

Hescot S. , Leboulleux S. , Amar L. , Borget I. , Vezzosi D. , Libe R. , Niccoli P. , Borson-Chazot F. , Do Cao C. , Tabarin A. , de la Fouchardiere C. , Raingeard I. , Chougnet C. , Gimenez-Roqueplo A. , Young J. , Bertherat J. , Wemeau J. , Bertagna X. , Schlumberger M. , Plouin P. , Baudin E.

Pheochromocytoma and paraganglioma are defined as malignant by the occurence of metastasis in extra paraganglionic sites. The natural evolution of these tumors remains unknown.The aim of our retrospective study was to define the progression-free survival (PFS) of untreated Malignant Pheochromocytoma and Paraganglioma (MPP) at 12 months (12 m-PFS) and to look for prognostic markers of 12 m-PFS. We analyzed clinical parameters of patients followed within 8...
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ea0029p1786 | Thyroid cancer | ICEECE2012

Is thyroid cancer recurrence risk increased after transplantation?

Tisset H. , Kamar N. , Faugeron I. , Pouteil-Noble C. , Klein M. , Frimat L. , Mourad G. , Drui D. , Do Cao C. , Vanthygem M. , Noel C. , Leenhardt L. , Rodien P. , Bonichon F. , Morelon E. , Leboulleux S. , Bournaud C. , Kelly A. , Niccoli P. , Schlumberger M. , Borson-Chazot F.

Context: An increased mortality by cancer is reported in grafted patients.Objective: This multicentric study aimed to investigate whether the prognosis of thyroid cancer was modified by transplantationResults: Sixty nine patients (35 M/34 F; median age 41 years) with a history of both thyroid cancer and transplantation were recruited via specialized networks (TUTHYREF and DIVAT). Evolution and outcome were retrospectively analyzed ...
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ea0026p70 | Endocrine tumours and neoplasia | ECE2011

First prognostic analysis of stage III adrenocartical carcinoma patients after complete resection: a retrospective French Multicentric Study from the INCA-COMETE network

Do Cao C , Leboulleux S , Borget I , Bertherat J , De la Fouchardiere C , Hecart A C , Caron P , Tabarin A , Niccoli P , Rohmer V , Drui D , Schillo F , Raingeard I , Young J , Ghuzlan A , Borson-Chazot F , Bertagna X , Pattou F , Wemeau J L , Francis Z , Libe R , Aubert S , Baudin E

Objective: To assess outcome of stage IIIĀ–ENSAT adrenocortical carcinoma (ACC) patients after complete macroscopic resection and prognostic factors for disease-free survival (DFS) and overall survival (OS).Methods: A retrospective review of 68 stage III ACC patients treated surgically between 1994 and 2009 in the French COMETE network was performed. Characteristics of patients were reviewed by a single investigator as well as the Weiss score by expe...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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